Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context

Matsukawa, T; Yin, MM; Baslan, T; Chung, YJ; Cao, DC; Bertoli, R; Zhu, YLJ; Walker, RL; Freeland, A; Knudsen, E; Lowe, SW; Meltzer, PS; Aplan, PD

Aplan, PD (通讯作者)，NCI, Genet Branch, Ctr Canc Res, NIH, 37 Room 6002,37 Convent Dr, Bethesda, MD 20892 USA.

FASEB JOURNAL, 2022; 36 (9):

Abstract

Minichromosome maintenance proteins (Mcm2-7) form a hexameric complex that unwinds DNA ahead of a replicative fork. The deficiency of Mcm proteins lea......

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