Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) alpha/gamma/delta Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate

Boubia, B; Poupardin, O; Barth, M; Binet, J; Peralba, P; Mounier, L; Jacquier, E; Gauthier, E; Lepais, V; Chatar, M; Ferry, S; Thourigny, A; Guillier, F; Llacer, J; Amaudrut, J; Dodey, P; Lacombe, O; Masson, P; Montalbetti, C; Wettstein, G; Luccarini

Boubia, B (reprint author), Inventiva, 50 Rue Dijon, F-21121 Daix, France.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (6): 2246

Abstract

Here, we describe the identification and synthesis of novel indole sulfonamide derivatives that activate the three peroxisome proliferator activated r......

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