DNA melting initiates the RAG catalytic pathway

Ru, H; Mi, W; Zhang, PF; Alt, FW; Schatz, DG; Liao, MF; Wu, H

Wu, H (reprint author), Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.; Wu, H (reprint author), Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA.; Liao, MF (reprint author), Harvard Med Sch, Dept Cell Biol, B

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018; 25 (8): 732

Abstract

The mechanism for initiating DNA cleavage by DDE-family enzymes, including the RAG endonuclease, which initiates V(D)J recombination, is not well unde......

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