Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension

Toshner, M; Church, C; Harbaum, L; Rhodes, C; Moreschi, SSV; Liley, J; Jones, R; Arora, A; Batai, K; Desai, AA; Coghlan, JG; Gibbs, JSR; Gor, D; Graf, S; Harlow, L; Hernandez-Sanchez, J; Howard, LS; Humbert, M; Karnes, J; Kiely, DG; Kittles, R; Knightbridge, E; Lam, B; Lutz, KA; Nichols, WC; Pauciulo, MW; Pepke-Zaba, J; Suntharalingam, J; Soubrier, F; Trembath, RC; Schwantes-An, THL; Wort, SJ; Wilkins, MR; Gaine, S; Morrell, NW; Corris, PA

Toshner, M (通讯作者)，Univ Cambridge, Dept Med, Cambridge, England.;Toshner, M (通讯作者)，Royal Papworth Hosp, Cambridge, England.

EUROPEAN RESPIRATORY JOURNAL, 2022; 59 (3):

Abstract

Background Inflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension (PAH). Compelling preclinical da......

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