Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS

Zhou, HY; Gao, F; Yang, XL; Lin, TT; Li, ZX; Wang, Q; Yao, Y; Li, L; Ding, XX; Shi, KB; Liu, Q; Bao, H; Long, ZY; Wu, ZJ; Vassar, R; Cheng, X; Li, RN; Shen, Y

Cheng, X (通讯作者)，Fudan Univ, Huashan Hosp, Natl Ctr Neurol Disorders, Natl Clin Res Ctr Aging & Med, Shanghai, Peoples R China.;Shen, Y (通讯作者)，Univ Sci & Technol China, Neurodegenerat Disorder Res Ctr, Sch Life Sci, 96 JinZhai Rd, Hefei 230026, Anhui, Peoples R China.;Li, RN (通讯作者)，Capital Med Univ, Beijing Inst Brain Disorders, Adv Innovat Ctr Human Brain Protect, Beijing Anding Hosp,Natl Clin Res Ctr Mental Diso, Beijing, Peoples R China.;Li, RN (通讯作者)，Capital Med Univ, Beijing Anding Hosp, Bei

CIRCULATION RESEARCH, 2022; 130 (9): 1321

Abstract

BACKGROUND: Cerebral small vessel injury, including loss of endothelial tight junctions, endothelial dysfunction, and blood-brain barrier breakdown, i......

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