Cholesterol-lowering drugs reduce APP processing to A beta by inducing APP dimerization

Langness, VF; van der Kant, R; Das, U; Wang, L; Chaves, RD; Goldstein, LSB

Goldstein, LSB (corresponding author), Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA.; Goldstein, LSB (corresponding author), Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.; Goldstein, LSB (corresponding author), Univ Calif San Diego, Sanford Consortium Regenerat Med, La Jolla, CA 92037 USA.; van der Kant, R (corresponding author), Vrije Univ Amsterdam, Dept Funct Genom, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam de Boelelaan 1087, NL-1081 HV A

MOLECULAR BIOLOGY OF THE CELL, 2021; 32 (3): 247

Abstract

Amyloid beta (A beta) is a major component of amyloid plaques, which are a key pathological hallmark found in the brains of Alzheimer's disease (AD) p......

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