Silencing the OCT4-PG1 pseudogene reduces OCT-4 protein levels and changes characteristics of the multidrug resistance phenotype in chronic myeloid leukemia

Lettnin, AP; Wagner, EF; Carrett-Dias, M; Machado, KD; Werhli, A; Canedo, AD; Trindade, GS; Votto, APD

Votto, APD (reprint author), Fundacao Univ Fed Rio Grande, Postgrad Program Physiol Sci PPGCF, Ave Italia,Km 8, BR-96203900 Rio Grande, RS, Brazil.; Votto, APD (reprint author), Fundacao Univ Fed Rio Grande, Lab Cell Culture, Inst Biol Sci ICB, Ave Italia

MOLECULAR BIOLOGY REPORTS, 2019; 46 (2): 1873

Abstract

Cancer stem cells show epigenetic plasticity and intrinsic resistance to anti-cancer therapy, rendering capable of initiating cancer relapse and progr......

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