Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Na(v)1.5

Hu, YS; Bai, XM; Zhang, C; Chakrabarti, S; Tang, B; Xiong, HB; Wang, ZJ; Yu, G; Xu, CQ; Chen, QY; Wang, QK

Xu, CQ (corresponding author), Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Ctr Human Genome Res, Key Lab Mol Biophys,Minist Educ, Wuhan 430074, Hubei, Peoples R China.; Chen, QY; Wang, QK (corresponding author), Cleveland Clin, Dept Cardiovasc & Metab Sci, Dept Cardiovasc Med, Lerner Res Inst, Cleveland, OH 44195 USA.; Chen, QY; Wang, QK (corresponding author), Case Western Reserve Univ, Dept Mol Med, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44195 USA.; Wang, QK (corresponding author), Case Western Reserve Univ, Dept Genet & Genome Sci, Sch Med, Cleveland, OH 44106 USA.

BIOCHEMICAL JOURNAL, 2020; 477 (9): 1683

Abstract

Cardiac sodium channel Na(v)1.5 is associated with cardiac arrhythmias and heart failure. Protein ubiquitination is catalyzed by an E1-E2-E3 cascade o......

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