Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives

Atkinson, BN; Woodward, HL; Sipthorp, J; Fish, PV

Fish, PV (reprint author), UCL, Alzheimers Res UK UCL Drug Discovery Inst, Cruciform Bldg,Gower St, London WC1E 6BT, England.

ORGANIC & BIOMOLECULAR CHEMISTRY, 2017; 15 (46): 9794

Abstract

A new efficient chiral synthesis of enantiopure arimoclomol (2) is reported from (R)-(-)-glycidyl nosylate (11) with complete retention of chiral inte......

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