A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

Chan, JFW; Oh, YJ; Yuan, SF; Chu, H; Yeung, ML; Canena, D; Chan, CCS; Poon, VKM; Chan, CCY; Zhang, AJ; Cai, JP; Ye, ZW; Wen, L; Yuen, TTT; Chik, KKH; Shuai, HP; Wang, YX; Hou, YX; Luo, CT; Chan, WM; Qin, ZZ; Sit, KY; Au, WK; Legendre, M; Zhu, R; Hain, L; Seferovic, H; Tampe, R; To, KKW; Chan, KH; Thomas, DG; Klausberger, M; Xu, C; Moon, JJ; Stadlmann, J; Penninger, JM; Oostenbrink, C; Hinterdorfer, P; Yuen, KY; Markovitz, DM

Yuen, KY (通讯作者),Univ Hong Kong, State Key Lab Emerging Infect Dis, Pokfulam, Hong Kong, Peoples R China.;Yuen, KY (通讯作者),Univ Hong Kong, Dept Microbiol, Sch Clin Med, Li Ka Shing Fac Med,Pokfulam, Hong Kong, Peoples R China.;Yuen, KY (通讯作者),Ctr Virol Vaccinol & Therapeut, Hong Kong Sci & Technol Pk, Hong Kong, Peoples R China.;Yuen, KY (通讯作者),Univ Hong Kong, Dept Infect Dis & Microbiol, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China.;Yuen, KY (通讯作者),Hainan Med Univ, Hainan Med Univ Univ Hon

CELL REPORTS MEDICINE, 2022; 3 (10):

Abstract

Pan-coronavirus'' antivirals targeting conserved viral components can be designed. Here, we show that the rationally engineered H84T-banana lectin (H8......

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