The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants

Cao, L; Li, YJ; Yang, SD; Li, GG; Zhou, QF; Sun, J; Xu, TF; Yang, Y; Liao, RY; Shi, YX; Yang, YJ; Zhu, TZ; Huang, SY; Ji, YX; Cong, F; Luo, YZ; Zhu, YJ; Luan, HM; Zhang, H; Chen, JD; Liu, X; Luo, RR; Liu, LH; Wang, P; Yu, Y; Xing, F; Ke, BX; Zheng, HY; Deng, XL; Zhang, WY; Lin, CW; Shi, M; Li, CM; Zhang, Y; Zhang, L; Dai, J; Lu, HZ; Zhao, JC; Zhang, XM; Guo, DY

Guo, DY (通讯作者),Sun Yat sen Univ, Sch Med, Ctr Infect & Immun Studies CIIS, Shenzhen Campus, Shenzhen 518107, Guangdong, Peoples R China.;Li, YJ; Zhang, XM (通讯作者),Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Coll Sci, Shenzhen Key Lab Small Mol Drug Discovery & Synt, Shenzhen 518055, Guangdong, Peoples R China.;Zhang, XM (通讯作者),Southern Univ Sci & Technol, Medi X Pingshan, Shenzhen 518118, Guangdong, Peoples R China.;Zhao, JC (通讯作者),Guangzhou Med Univ, Affiliated Hosp 1, Guang

SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (661):

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus driving the ongoing coronavirus disease 2019 (COVID-19) pandemic, continues to......

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