Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors

Li, XY; Shi, BY; Teng, Y; Cheng, Y; Yang, HZ; Li, JR; Wang, LJ; He, SY; You, QD; Xiang, H

Xiang, H (reprint author), China Pharmaceut Univ, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China.

MEDCHEMCOMM, 2019; 10 (2): 294

Abstract

BTK is an effective target for the treatment of B-cell malignant tumors and autoimmune diseases. In this work, a series of 2-phenyl pyrimidine derivat......

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