cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

Xiao, NY; Wei, JJ; Xu, S; Du, HK; Huang, MH; Zhang, ST; Ye, WW; Sun, LJ; Chen, Q

Chen, Q (reprint author), Fujian Normal Univ, Coll Life Sci, Biomed Res Ctr South China, Fujian Key Lab Innate Immune Biol, Fuzhou 350117, Fujian, Peoples R China.; Sun, LJ (reprint author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, T

JOURNAL OF AUTOIMMUNITY, 2019; 100 (): 84

Abstract

TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases i......

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