Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A)

Borrello, MT; Schinor, B; Bartels, K; Benelkebir, H; Pereira, S; Al-Jamal, WT; Douglas, L; Duriez, PJ; Packham, G; Haufe, G; Ganesan, A

Ganesan, A (reprint author), Univ East Anglia, Sch Pharm, Norwich Res Pk, Norwich NR4 7TJ, Norfolk, England.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (10): 2099

Abstract

We report a series of tranylcypromine analogues containing a fluorine in the cyclopropyl ring. A number of compounds with additional m- or p-substitut......

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