Neuraminidase-mediated desialylation augments AAV9-mediated gene expression in skeletal muscle

Zhu, HL; Wang, T; Lye, RJ; French, BA; Annex, BH

French, BA (reprint author), Univ Virginia, Dept Biomed Engn, 415 Lane Rd,MR5 Bldg,Room 1219,Box 800759, Charlottesville, VA 22908 USA.

JOURNAL OF GENE MEDICINE, 2018; 20 (9):

Abstract

BackgroundFollowing systemic delivery, AAV9-mediated gene expression is significantly increased in ischemic versus non-ischemic muscle, suggesting tha......

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