Afadin cooperates with Claudin-2 to promote breast cancer metastasis

Tabaries, S; McNulty, A; Ouellet, V; Annis, MG; Dessureault, M; Vinette, M; Hachem, Y; Lavoie, B; Omeroglu, A; Simon, HG; Walsh, LA; Kimbung, S; Hedenfalk, I; Siegel, PM

Siegel, PM (reprint author), McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada.; Siegel, PM (reprint author), McGill Univ, Dept Med, Montreal, PQ H3A 1A3, Canada.; Siegel, PM (reprint author), McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3,

GENES & DEVELOPMENT, 2019; 33 (3-4): 180

Abstract

Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that the PDZ-binding motif of......

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