Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles-MedSci.cn

Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles

Yu, ZT; He, XQ; Wang, RL; Xu, XX; Zhang, Z; Ding, K; Zhang, ZM; Tan, Y; Li, ZQ

Ding, K; Zhang, ZM; Tan, Y (通讯作者)，Jinan Univ, Int Cooperat Lab Tradit Chinese Med Modernizat & I, Guangzhou City Key Lab Precis Chem Drug Dev, Guangzhou 510632, Peoples R China.;Ding, K; Zhang, ZM; Tan, Y; Li, ZQ (通讯作者)，Jinan Univ, Sch Pharm, Guangzhou 510632, Peoples R China.;Li, ZQ (通讯作者)，Jinan Univ, Int Cooperat Lab Tradit Chinese Med Modernizat & I, MOE Key Lab Tumor Mol Biol, Guangzhou City Key Lab Precis Chem Drug Dev, Guangzhou 510632, Peoples R China.

Abstract

Owing to their remarkable pharmaceutical properties comparedtothose of noncovalent inhibitors, the development of targeted covalentinhibitors (TCIs) h......

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Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles

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