The discovery and development of binimetinib for the treatment of melanoma

Tran, B; Cohen, MS

Cohen, MS (corresponding author), Univ Michigan Hosp & Hlth Syst, Surg Pharmacol & Biomed Engn, Dept Surg, 2920A Taubman Ctr SPC 5331,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.; Cohen, MS (corresponding author), Univ Michigan Hosp & Hlth Syst, Clin Operat, Dept Surg, 2920A Taubman Ctr SPC 5331,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.; Cohen, MS (corresponding author), Univ Michigan Hosp & Hlth Syst, Med Sch Pathway Excellence Innovat & Entrepreneur, Dept Surg, 2920A Taubman Ctr SPC 5331,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.; Cohen, MS (corresponding author), Univ Michigan Hosp & Hlth Syst, Michigan Surg Innovat Prize Fund, Dept Surg, 2920A Taubman Ctr SPC 5331,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.; Cohen, MS (corresponding author), Univ Michigan Hosp & Hlth Syst, Endocrine Surg Res, Dept Surg, 2920A Taubman Ctr SPC 5331,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.

EXPERT OPINION ON DRUG DISCOVERY, 2020; 15 (7): 745

Abstract

Introduction: Binimetinib is an uncompetitive, small-molecule inhibitor of selective mitogen-activated protein kinase (MEK1/2) and was recently approv......

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