Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins

Zhu, YL; Gao, A; Zhan, Q; Wang, Y; Feng, H; Liu, SQ; Gao, GX; Serganov, A; Gao, P

Gao, P (reprint author), Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, CAS Key Lab Infect & Immun,CAS Ctr Excellence Bio, Beijing 100101, Peoples R China.; Serganov, A (reprint author), NYU, Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 1001

MOLECULAR CELL, 2019; 74 (2): 296

Abstract

Anti-CRISPR proteins (Acrs) targeting CRISPR-Cas9 systems represent natural "off switches" for Cas9-based applications. Recently, AcrIIC1, AcrIIC2, an......

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