Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis

Kong, Q; Xia, SY; Pan, XX; Ye, KX; Li, ZYH; Li, HY; Tang, XQ; Sahni, N; Yi, SS; Liu, X; Wu, H; Elowitz, MB; Lieberman, J; Zhang, ZB

Kong, Q; Zhang, ZB (通讯作者)，Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77054 USA.

SCIENCE IMMUNOLOGY, 2023; 8 (82):

Abstract

Granzyme A from killer lymphocytes cleaves gasdermin B (GSDMB) and triggers pyroptosis in targeted human tumor cells, eliciting antitumor immunity. Ho......

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