Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics

Ferrante, F; Giaimo, BD; Friedrich, T; Sugino, T; Mertens, D; Kugler, S; Gahr, BM; Just, S; Pan, LL; Bartkuhn, M; Potente, M; Oswald, F; Borggrefe, T

Borggrefe, T (通讯作者)，Univ Giessen, Inst Biochem, Friedrichstr 24, D-35392 Giessen, Germany.

CELL DEATH & DISEASE, 2022; 13 (7):

Abstract

Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Not......

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