BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1

Li, LM; Wang, LC; Liu, D; Zhao, YC

Zhao, YC (通讯作者),Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Peoples R China.;Zhao, YC (通讯作者),Zhejiang Univ, Affiliated Hosp 1, Sch Med, Zhejiang Prov Key Lab Pancreat Dis, Hangzhou, Peoples R China.;Zhao, YC (通讯作者),Zhejiang Univ, Inst Translat Med, Sch Med, Hangzhou, Peoples R China.;Zhao, YC (通讯作者),Zhejiang Univ, Canc Ctr, Hangzhou, Peoples R China.

CELL DEATH DISCOVERY, 2023; 9 (1):

Abstract

Checkpoint kinase 1 (CHK1), a key effector in the cellular response to DNA lesions, is a crucial component of all cell cycle checkpoints. Recent repor......

Full Text Link