Low-Dose Linaclotide (72 mu g) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

Schoenfeld, P; Lacy, BE; Chey, WD; Lembo, AJ; Kurtz, CB; Reasner, DS; Bochenek, W; Tripp, K; Currie, MG; Fox, SM; Blakesley, RE; O'Dea, CR; Omniewski, ND; Hall, ML

Hall, ML (reprint author), Ironwood Pharmaceut Inc, 301 Binney St, Cambridge, MA 02141 USA.

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2018; 113 (1): 105

Abstract

OBJECTIVES: Linaclotide is a guanylate cyclase-C agonist approved in the United States, Canada, and Mexico at a once-daily 145-mu g dose for the treat......

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