Effects of germ me DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Tulstrup, M; Moriyama, T; Jiang, C; Grosjean, M; Nersting, J; Abrahamsson, J; Grell, K; Hjalgrim, LL; Jonsson, OG; Kanerva, J; Lund, B; Nielsen, SN; Nielsen, RL; Overgaard, U; Quist-Paulsen, P; Pruunsild, K; Vaitkeviciene, G; Wolthers, BO; Zhang, H; Gupta, R; Yang, JJ; Schmiegelow, K

Schmiegelow, K (corresponding author), Rigshosp, Univ Hosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

BLOOD, 2020; 136 (10): 1161

Abstract

Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate tre......

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