POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

Belan, O; Sebald, M; Adamowicz, M; Anand, R; Vancevska, A; Neves, J; Grinkevich, V; Hewitt, G; Segura-Bayona, S; Bellelli, R; Robinson, HMR; Higgins, GS; Smith, GCM; West, SC; Rueda, DS; Boulton, SJ

Boulton, SJ (通讯作者)，Francis Crick Inst, DSB Repair Metab Lab, London NW1 1AT, England.;Boulton, SJ (通讯作者)，Artios Pharma Ltd, B940 Babraham Res Campus, Cambridge CB22 3FH, England.

MOLECULAR CELL, 2022; 82 (24): 4664

Abstract

POLQ is a key effector of DSB repair by microhomology-mediated end-joining (MMEJ) and is overex-pressed in many cancers. POLQ inhibitors confer synthe......

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