RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling

Yao, Z; Gao, YJ; Su, WJ; Yaeger, R; Tao, J; Na, N; Zhang, Y; Zhang, C; Rymar, A; Tao, A; Timaul, NM; Mcgriskin, R; Outmezguine, NA; Zhao, H; Chang, Q; Qeriqi, B; Barbacid, M; de Stanchina, E; Hyman, DM; Bollag, G; Rosen, N

Rosen, N (reprint author), Mem Sloan Kettering Canc Ctr, Program Mol Pharmacol, 1275 York Ave, New York, NY 10021 USA.; Rosen, N (reprint author), Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.; Rosen, N (reprint author), M

NATURE MEDICINE, 2019; 25 (2): 284

Abstract

Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF V600 mutant alleles which can fu......

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