Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth

Yao, N; Wang, CR; Liu, MQ; Li, YJ; Chen, WM; Li, ZQ; Qi, Q; Lu, JJ; Fan, CL; Chen, MF; Qi, M; Li, XB; Hong, J; Zhang, DM; Ye, WC

Zhang, DM; Ye, WC (corresponding author), Jinan Univ, Coll Pharm, Guangzhou, Peoples R China.; Zhang, DM; Ye, WC (corresponding author), Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China.

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020; 5 (1):

Abstract

Epidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-small cell lung cancer (NSCLC) and is considered as a key t......

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