Insight into the Nucleotide Based Modulation of the Grp94 Molecular Chaperone Using Multiscale Dynamics

Alao, JP; Obaseki, I; Amankwah, YS; Nguyen, Q; Sugoor, M; Unruh, E; Popoola, HO; Tehver, R; Kravats, AN

Kravats, AN (通讯作者)，Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.;Kravats, AN (通讯作者)，Miami Univ, Dept Chem & Biochem, Cell Mol Struct Biol Program, Oxford, OH 45056 USA.

JOURNAL OF PHYSICAL CHEMISTRY B, 2023; 127 (24): 5389

Abstract

Grp94, an ER-localized molecular chaperone, is requiredfor thefolding and activation of many membrane and secretory proteins. Clientactivation by Grp9......

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