BAFF-driven NLRP3 inflammasome activation in B cells

Lim, KH; Chen, LC; Hsu, KT; Chang, CC; Chang, CY; Kao, CW; Chang, YF; Chang, MC; Chen, CG

Chen, CG (corresponding author), MacKay Mem Hosp, Dept Hematol, Taipei 10449, Taiwan.; Chen, CG (corresponding author), MacKay Med Coll, Dept Med, New Taipei 25245, Taiwan.; Chen, CG (corresponding author), Mackay Mem Hosp, GCRC Lab, Dept Hematol, New Taipei 25160, Taiwan.; Chen, CG (corresponding author), MacKay Jr Coll Med Nursing & Management, Dept Nursing, New Taipei, Taiwan.; Chen, CG (corresponding author), Natl Tsing Hua Univ, Inst Mol Med, Hsinchu, Taiwan.

CELL DEATH & DISEASE, 2020; 11 (9):

Abstract

BAFF supports B-cell survival and homeostasis by activating the NF-kappa B pathway. While NF-kappa B is also involved in the priming signal of NLRP3 i......

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