KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target

Wei, Y; Ren, XX; Galbo, PM; Moerdler, S; Wang, H; Sica, RA; Etemad-Gilbertson, B; Shi, L; Zhu, LQ; Tang, XD; Lin, Q; Peng, M; Guan, FX; Zheng, DY; Chinai, JM; Zang, XX

Zang, XX (corresponding author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.; Zang, XX (corresponding author), Montefiore Med Ctr, Dept Med, Bronx, NY 10461 USA.; Zang, XX (corresponding author), Montefiore Med Ctr, Dept Urol, Bronx, NY 10461 USA.

SCIENCE IMMUNOLOGY, 2021; 6 (61):

Abstract

The B7 family ligand HERV-H LTR-associating protein 2 (HHLA2) is an attractive target for cancer immunotherapy because of its coinhibitory function, o......

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