A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces

Li, JY; Wang, WX; Liu, X; Tian, YQ; Tan, HR; Zhang, JH

Tan, HR; Zhang, JH (通讯作者)，Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China.

METABOLIC ENGINEERING, 2022; 72 (): 289

Abstract

Secondary metabolic gene clusters widely exist in the genomes of Streptomyces but mostly remain silent. To awaken this hidden reservoir of natural pro......

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