Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity

Termini, JM; Martinez-Navio, JM; Gao, GP; Fuchs, SP; Desrosiers, RC

Desrosiers, RC (corresponding author), Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2021; 20 (): 204

Abstract

The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxi......

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