Downregulation of the FTO m(6)A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors

Jeschke, J; Collignon, E; Al Wardi, C; Krayem, M; Bizet, M; Jia, Y; Garaud, S; Wimana, Z; Calonne, E; Hassabi, B; Morandini, R; Deplus, R; Putmans, P; Dube, G; Singh, NK; Koch, A; Shostak, K; Rizzotto, L; Ross, RL; Desmedt, C; Bareche, Y; Rothe, F; Lehmann-Che, J; Duterque-Coquillaud, M; Leroy, X; Menschaert, G; Teixeira, L; Guo, MZ; Limbach, PA; Close, P; Chariot, A; Leucci, E; Ghanem, G; Yuan, BF; Willard-Gallo, K; Sotiriou, C; Marine, JC; Fuks, F

Fuks, F (corresponding author), Univ Libre Bruxelles ULB, ULB Canc Res Ctr U CRC, Fac Med, Lab Canc Epigenet, Brussels, Belgium.; Fuks, F (corresponding author), Univ Libre Bruxelles ULB, WELBIO, Brussels, Belgium.

NATURE CANCER, 2021; 2 (6): 611

Abstract

Post-transcriptional modifications of RNA constitute an emerging regulatory layer of gene expression. The demethylase fat mass- and obesity-associated......

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