CD8+T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

Huseni, MA; Wang, LF; Klementowicz, JE; Yuen, K; Breart, B; Orr, C; Liu, LF; Li, YJ; Gupta, V; Li, CF; Rishipathak, D; Peng, J; Senbabaoglu, Y; Modrusan, Z; Keerthivasan, S; Madireddi, S; Chen, YJ; Fraser, EJ; Leng, N; Hamidi, H; Koeppen, H; Ziai, J; Hashimoto, K; Fassò, M; Williams, P; McDermott, DF; Rosenberg, JE; Powles, T; Emens, LA; Hegde, PS; Mellman, I; Turley, SJ; Wilson, MS; Mariathasan, S; Molinero, L; Merchant, M; West, NR

Huseni, MA; West, NR (通讯作者)，Genentech Inc, San Francisco, CA 94080 USA.

CELL REPORTS MEDICINE, 2023; 4 (1):

Abstract

Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies, overcoming ther-apeutic resistance remains a critical chal......

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