Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing

Bi, CW; Wang, L; Fan, Y; Yuan, BL; Ramos-Mandujano, G; Zhang, YZ; Alsolami, S; Zhou, X; Wang, JC; Shao, YJ; Reddy, P; Zhang, PY; Huang, YY; Yu, Y; Belmonte, JCI; Li, M

Belmonte, JCI; Li, M (通讯作者),King Abdullah Univ Sci & Technol KAUST, Biosci program, Biol & Environm Sci & Engn Div, Thuwal 239556900, Saudi Arabia.;Li, M (通讯作者),King Abdullah Univ Sci & Technol KAUST, Bioengn Program, Biol & Environm Sci & Engn Div, Thuwal 239556900, Saudi Arabia.;Belmonte, JCI (通讯作者),Altos Labs, San Diego, CA 92121 USA.;Yu, Y (通讯作者),Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China.;Yu, Y (通讯作者),Peking Univ Third Hosp, Stem Cell Res Ctr, Beijing 100191, Peoples R China.

NUCLEIC ACIDS RESEARCH, 2023; 51 (8):

Abstract

The ontogeny and dynamics of mtDNA heteroplasmy remain unclear due to limitations of current mtDNA sequencing methods. We developed individual Mitocho......

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