Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells

Zhang, QW; Wang, CX; Cannavicci, A; Faughnan, ME; Kutryk, MJB

Kutryk, MJB (corresponding author), Univ Toronto, Keenan Res Ctr Biomed Sci, St Michaels Hosp, Unity Hlth Toronto,Div Cardiol, 209 Victoria St, Toronto, ON M5B 1T8, Canada.

TRANSLATIONAL RESEARCH, 2021; 235 (): 129

Abstract

Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease characterized by vascular dysplasia. Mutations of the endoglin (ENG) gene that encode......

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