Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Tallon, C; Bell, BJ; Sharma, A; Pal, A; Malvankar, MM; Thomas, AG; Yoo, SW; Hollinger, KR; Coleman, K; Wilkinson, EL; Kannan, S; Haughey, NJ; Kannan, RM; Rais, R; Slusher, BS

Rais, R; Slusher, BS (通讯作者)，Johns Hopkins Drug Discovery, Baltimore, MD 21205 USA.;Rais, R; Slusher, BS (通讯作者)，Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21205 USA.;Slusher, BS (通讯作者)，Johns Hopkins Univ, Wilmer Eye Inst, Dept Chem & Biomol Engn, Sch Med,Ctr Nanomed, Baltimore, MD 21205 USA.;Rais, R; Slusher, BS (通讯作者)，Johns Hopkins Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.;Slusher, BS (通讯作者)，Johns Hopkins Sch Med, Johns Hopkins Drug Discovery, Baltimore, MD 21205 U

PHARMACEUTICS, 2022; 14 (10):

Abstract

Alzheimer's disease (AD) is characterized by the progressive accumulation of amyloid-beta and hyperphosphorylated tau (pTau), which can spread through......

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