Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist

Zuo, C; Shi, WW; Chen, XX; Glatz, M; Riedl, B; Flamme, I; Pook, E; Wang, JW; Fang, GM; Bierer, D; Liu, L

Liu, L (reprint author), Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Ctr Synthet & Syst Biol, Tsinghua Peking Ctr Life Sci,Minist Educ,Dept Che, Beijing 100084, Peoples R China.

SCIENCE CHINA-CHEMISTRY, 2019; 62 (10): 1371

Abstract

Blockade of the interaction of anaphylatoxin C5a with its receptor C5aR1 has been actively studied as a potential treatment for many inflammatory dise......

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