Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Longo, DM; Woodhead, JL; Walker, P; Heredi-Szabo, K; Mogyorosi, K; Wolenski, FS; Dragan, YP; Mosedale, M; Siler, SQ; Watkins, PB; Howell, BA

Longo, DM (reprint author), 6 Davis Dr,POB 12317, Res Triangle Pk, NC 27709 USA.

TOXICOLOGICAL SCIENCES, 2019; 167 (2): 458

Abstract

TAK-875 (fasiglifam), a GPR40 agonist in development for the treatment of type 2 diabetes (T2D), was voluntarily terminated in Phase III trials due to......

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