Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity

Xie, XL; Baird, D; Bowen, K; Capka, V; Chen, JY; Chenail, G; Cho, YS; Dooley, J; Farsidjani, A; Fortin, P; Kohls, D; Kulathila, R; Lin, F; McKay, D; Rodrigues, L; Sage, D; Toure, BB; van der Plas, S; Wright, K; Xu, M; Yin, H; Levell, J; Pagliarini, R

Pagliarini, RA (reprint author), Novartis Inst Biomed Res, Oncol, 250 Massachusetts Ave, Cambridge, MA 02139 USA.

STRUCTURE, 2017; 25 (3): 506

Abstract

Oncogenic IDH1 and IDH2 mutations contribute to cancer via production of R-2-hydroxyglutarate (2-HG). Here, we characterize two structurally distinct ......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索