Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival

Rahman, MA; Navarro, AG; Brekke, J; Engelsen, A; Bindesboll, C; Sarowar, S; Bahador, M; Bifulco, E; Goplen, D; Waha, A; Lie, SA; Gjertsen, BT; Selheim, F; Enger, PO; Simonsen, A; Chekenya, M

Chekenya, M (reprint author), Univ Bergen, Dept Biomed, Bergen, Norway.

BRITISH JOURNAL OF CANCER, 2019; 121 (7): 545

Abstract

BACKGROUND: Resistance to temozolomide (TMZ) is due in part to enhanced DNA repair mediated by high expression of O-6-methyl guanine DNA methyltransfe......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索