The pan-PPAR agonist lanifibranor reduces development of lung fibrosis and attenuates cardiorespiratory manifestations in a transgenic mouse model of systemic sclerosis

Derrett-Smith, E; Clark, KEN; Xu, SW; Abraham, DJ; Hoyles, RK; Lacombe, O; Broqua, P; Junien, JL; Konstantinova, I; Ong, VH; Denton, CP

Denton, CP (corresponding author), Ctr Rheumatol & Connect Tissue Dis, UCL Div Med, Rowland Hill St, London NW3 2PF, England.

ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1):

Abstract

Background: The T beta RII Delta k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic ......

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