Inhibition of phosphodiesterase 12 results in antiviral activity against several RNA viruses including SARS- CoV-2

Thursz, M; Sadiq, F; Tree, JA; Karayiannis, P; Beasley, DWC; Dejnirattisai, W; Mongkolsapaya, J; Screaton, G; Wand, M; Elmore, MJ; Carroll, MW; Matthews, I; Thomas, H

Thomas, H (通讯作者)，Imperial Coll, Dept Metab Digest & Reprod, London W2 1NY, England.;Karayiannis, P (通讯作者)，Univ Nicosia, Med Sch, Nicosia, Cyprus.;Karayiannis, P; Thomas, H (通讯作者)，RioTech Pharmaceut, 49 Arrivato Pl, St Helens WA10 1GH, England.

JOURNAL OF GENERAL VIROLOGY, 2023; 104 (7):

Abstract

The 2',5'- oligoadenylate synthetase (OAS) - ribonuclease L (RNAseL) - phosphodiesterase 12 (PDE12) pathway is an essential interferon- induced effect......

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