Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice

Ling, SK; Yang, SQ; Hu, XD; Yin, D; Dai, Y; Qian, XQ; Wang, DW; Pan, XY; Hong, JX; Sun, XD; Yang, H; Paludan, SR; Cai, YJ

Cai, YJ (corresponding author), Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, Minist Educ, Shanghai, Peoples R China.

NATURE BIOMEDICAL ENGINEERING, 2021; 5 (2):

Abstract

Therapeutic genome editing requires effective and targeted delivery methods. The delivery of Cas9 mRNA using adeno-associated viruses has led to poten......

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