Structural Basis of PER-1-Mediated Cefiderocol Resistance and Synergistic Inhibition of PER-1 by Cefiderocol in Combination with Avibactam or Durlobactam in Acinetobacter baumannii

Liu, XC; Lei, TL; Yang, YX; Zhang, LH; Liu, HY; Leptihn, S; Yu, YS; Hua, XT

Yu, YS; Hua, XT (通讯作者)，Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Infect Dis, Hangzhou, Peoples R China.;Yu, YS; Hua, XT (通讯作者)，Key Lab Microbial Technol & Bioinformat Zhejiang P, Hangzhou, Peoples R China.;Yu, YS; Hua, XT (通讯作者)，Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Reg Med Ctr,Natl Inst Resp Dis, Hangzhou, Peoples R China.;Hua, XT (通讯作者)，Alibaba Zhejiang Univ Joint Res Ctr Future Digital, Hangzhou, Peoples R China.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2022; 66 (12):

Abstract

Cefiderocol is a novel siderophore cephalosporin that displays activity against Gram-negative bacteria. To establish cefiderocol susceptibility levels......

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