Unexpected cross-reactivity of anti-cathepsin B antibodies leads to uncertainties regarding the mechanism of action of anti-CD20 monoclonal antibody GA101

Chien, WW; Niogret, C; Juge, R; Lionnard, L; Cornut-Thibaut, A; Kucharczak, J; Savina, A; Salles, G; Aouacheria, A

Savina, A; Salles, G (reprint author), Inst Roche, 30 Cours Ile Seguin, F-92650 Boulogne, France.; Aouacheria, A (reprint author), Univ Montpellier, ISEM, UMR 5554, CNRS,IRD,CIRAD,EPHE, Pl Eugene Bataillon, F-34095 Montpellier, France.

LEUKEMIA RESEARCH, 2017; 55 ( ): 41

Abstract

GA101, also known as obinutuzumab or Gazyva (Gazyvaro), is a glycoengineered type II humanized antibody that targets the CD20 antigen expressed at the......

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