Role of substituents in the Hofmann-Loffler-Freytag reaction. A quantum-chemical case study on nicotine synthesis

Shkunnikova, S; Zipse, H; Sakic, D

Sakic, D (corresponding author), Univ Zagreb, Fac Pharm & Biochem, Ante Kovacica 1, Zagreb 10000, Croatia.

ORGANIC & BIOMOLECULAR CHEMISTRY, 2021; 19 (4): 854

Abstract

The Hofmann-Loffler-Freytag (HLF) reaction can be successfully used to synthesize saturated heterocyclic nitrogen-containing nature-derived pharmaceut......

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