Arolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway

Zhu, ZY; Lu, JF; Wang, SY; Peng, WJ; Yang, Y; Chen, C; Zhou, X; Yang, XF; Xin, WJ; Chen, XY; Pi, JK; Yin, W; Yao, L; Pi, RB

Pi, RB (通讯作者)，Sun Yat Sen Univ, Sch Med, Guangzhou 518000, Peoples R China.;Yin, W (通讯作者)，Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510089, Peoples R China.;Yao, L (通讯作者)，Shandong Univ Tradit Chinese Med, Res Inst Acupuncture & Moxibust, Jinan, Peoples R China.

AGING CELL, 2022; 21 (4):

Abstract

Acrolein, an unsaturated aldehyde, is increased in the brain of Alzheimer's disease (AD) patients and identified as a potential inducer of sporadic AD......

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