A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Yang, YT; Zhang, ZX; Li, P; Kong, WM; Liu, XD; Liu, L

Liu, XD; Liu, L (corresponding author), China Pharmaceut Univ, Ctr Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China.

PHARMACEUTICS, 2021; 13 (5):

Abstract

Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine tran......

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