A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibits downstream signaling, and alleviates inflammation

Zhang, M; Ma, XY; Xu, HL; Wu, WB; He, X; Wang, XY; Jiang, M; Hou, YY; Bai, G

Hou, YY; Bai, G (reprint author), Nankai Univ, State Key Lab Med Chem Biol, Coll Pharm, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China.; Hou, YY; Bai, G (reprint author), Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd

FEBS JOURNAL, 0; ():

Abstract

Swertiamarin (SW), a representative component in Flos Lonicerae Japonicae, has been reported to exert significant activity in preventing infections. I......

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